Treatment of Epidermolysis Bullosa

Angela Gibson, MD
University of Wisconsin School of Medicine and Public Health, Madison, WI


Patient Presentation

  • In September 2019, a 2-year-old boy with epidermolysis bullosa (EB) presented with a partial-thickness armpit blister.
  • After 2 days of standard-of-care treatment, his armpit turned into a full-thickness blister, resulting in a macerated wound.
  • Microlyte® was suggested as an alternate therapy, and permission was granted 5 days later, during which time one more standard-of-care dressing change occurred.

Procedure & Treatment

  • Microlyte® was applied at days 1, 3, 4, 10 and 12 in combination with Kurlex gauaze bandages

Clinical Outcome

  • Treatment with Microlyte® appeared to contribute to significant closure of the EB blister wound.
  • EB is a rare genetic disease of connective tissue that involves severe blistering of the skin from minor damage such as heat, rubbing, scratching or adhesive tape removal.
  • In addition to enduring daily painful dressing changes, EB patients are at constant risk for infection and sepsis due to multiple open wounds.
  • Because there is no cure, treatment focuses on caring for blisters, preventing new ones and protecting non-blistered skin.
  • Microlyte® application to a severe full-thickness blister, lead to unprecedented improvement in patient’s wounds.
  • Importantly, because Microlyte® is completely bioresorbable, the matrix did not need to be removed, resulting in decreased pain and increased quality of life.
  • Microlyte® shows promise as an adjunct therapy for patients with partial- and full-thickness wounds arising from epidermolysis bullosa.




DAY 10

Day 12

Download Whitepaper