A wound matrix made of synthetic, resorbable polymers that is also antimicrobial?

That’s a first.

Microlyte® Matrix absorbs wound fluid and transforms into a bioresorbable material that intimately contours to the underlying wound bed. It maintains a physiologically moist microenvironment. In vitro and in vivo, studies indicate that components of the matrix allow cell growth and neovascularization. 1,2,3

A Unique Matrix

Wounds are messy and disorganized places, to the naked eye and on the microscopic level.  Even in the cleanest surgical wounds, the wound bed can be a challenging place for the cells that heal wounds to establish a foothold and proliferate.  This is particularly true if the patient has underlying comorbidities that impair normal wound healing (e.g., diabetes, vascular disease, etc.).

The polyelectrolyte matrix in Microlyte® Matrix is one-of-a-kind.  It is extremely thin but it masks the disorganized surface chemistry of the wound bed and provides a template for cells to facilitate granulation tissue formation and wound healing.

Synthetic and Bioresorbable

Microlyte is a synthetic wound matrix. This means that Microlyte® Matrix does not contain any human or animal derived tissues or cells, so it does not possess the risks inherent to allogenic and xenophobia genie products.

Microlyte® Matrix is also composed of a resorbable polymer–polyvinyl alcohol (PVA).  PVA, which is on the U.S. Food and Drug Administration’s (FDA) “generally recognized as safe” list, is a component of many drug formulations, cosmetics , and personal care items.  In Microlyte® Matrix, PVA absorbs wound fluid and helps maintain a moist wound environment.

The components of Microlyte® Matrix either get sloughed from the wound as it heals or are excreted by the body through normal processes.  That means that once your wound is healed, Microlyte® Matrix is gone.

Hydration and Healing

Maintaining a moist wound environment is critical for proper wound healing. Decades of research show that wound heal three to five time faster when kept moist. There are several specific ways that maintaining moisture at the wound bed help:

  • Wound healing take less time
  • Wound cells (keratinocytes) function more easily
  • Autolytic debridement is facilitated
  • Decreases incidence of wound infection
  • Preserves growth factors in wound fluid
  • Stimulates collagen synthesis
  • Reduces Pain
  • Reduces Scarring

The hydrophilic polyvinyl alcohol resorbable polymer component of the Microlyte® Matrix, keeps wound moisture where it is needed—at the wound bed—to further support wound healing.

Antimicrobial Activity

Microlyte contains bacteria-killing antimicrobial silver. Reduction of bacterial bioburden may reduce microbial colonization and risks of wound infection. This addition of ionic and metallic silver provides rapid, effective, and sustained antimicrobial activity.5

  • 510k-cleared for multiday antimicrobial effect
  • >99.99% effective against a broad spectrum of wound-related microbes.4,5

“We like using this a lot, especially in wounds that have an irregular surface. It conforms to the wound base very readily. The multi-day antimicrobial effect is nice for wounds that may require compression or a secondary dressing that we don’t want to change everyday.”

Jeffrey A. Niezgoda, MD, FACHM, MAPWCA, CHWS
President and Medical Director AZH Wound and Vascular

Case Studies

More Clinical Cases

“I was recently hospitalized for a wound on the back of my heel that resulted in a Staph infection. Being a diabetic, I was told it could take months to heal. I received two applications of Microlyte, and the wound healed. My doctor and his staff were flabbergasted by the change in only 2 weeks! This has been life-changing! I am shocked and beyond grateful for Microlyte!”

Chad G.
Dekalb, Illinois

Economics of Microlyte in Chronic wound treatment

  • 8 DFU (across 6 patients) treated with Microlyte Matrix at Mission Hospital (Asheville, NC)
  • All wounds classified as stalled with average non-healing time of 53 weeks
  • Standards of care, including topical ABX and offloading, failed to produce wound closure
  • Microlyte treatment resulted in an average closure of 79% in 3-12 weeks, with 90% reduction in treatment cost

REFERENCES 1 A Agarwal, et al. Biomaterials, 31 (4), 680-690, 2010. 2 Systemic Toxicity, Local Tissue Response, and Wound Healing Study of Microlyte Ag wound dressing, Following Repeated Treatment to Full-Thickness Wounds in Rats – 28 Days. Study 15T_41113_02, 2015. Data on file, Imbed Biosciences. 3 MTT cytotoxicity testing conducted at NAMSA. Data on file at Imbed Biosciences. 4 FDA 510k application. Data on file, Imbed Biosciences. 5 As demonstrated in vitro

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